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This product is used to quantitatively determine the content of creatinine in human urine.
Creatinine is a low-molecular-weight nitrogen-containing compound and is the end product of creatine metabolism.
It is excreted by the glomerulus and is not reabsorbed by the renal tubules.
The amount of creatinine in food has little effect on the amount of creatinine elimination. When the renal function is normal, the elimination rate of creatinine is quite constant, which is proportional to the amount of endogenous creatinine production.
Normal reference range: female 2550-20000μmol/L; male 3540-24600μmol/L (first morning urine)
The determination of urine creatinine has very important clinical significance in the diagnosis of diabetic nephropathy:
1) When kidney function is impaired, the normal excretion of creatinine is hindered, resulting in a decrease in urine creatinine content
2) Decrease in urine creatinine indicates impaired renal function, and urine creatinine is an important indicator of kidney function