Lp-PLA2（脂蛋白相關(guān)磷脂酶A2）
Lipoprotein-Associated Phospholipase A2 Chemiluminescent Immunoassay ?? Description Lp-PLA2, or lipoprotein-associated phospholipase-A2, measures disease activity within the artery wall below the collagen or calcified cap due to the activation of macrophages. Lp-PLA2 is not an acute phase reactant. When disease is active in the artery, increased levels of Lp-PLA2 are produced by macrophages and foam cells within the intima of the artery1. Lp-PLA2 also interacts with oxidized LDL, which increases inflammation and enhances a proatherogenic state, as well as plaque vulnerability2. Research suggests that it plays a direct role in the atherosclerotic disease process. ?? How Does it Work? 1）Lp-PLA2 accumulates within human atherosclerotic plaques and vulnerable lesions. 2）Elevated Lp-PLA2 levels can predict the development of coronary artery disease in apparently healthy individuals and the risk of future adverse cardiac and cerebrovascular events. 3）Individuals with normal systolic blood pressure, but high Lp-PLA2 levels, are 2x as likely to have a stroke, while those with elevated systolic blood pressure and Lp-PLA2 levels are 7x more likely to experience a stroke. 4）Post-menopausal women not using hormone therapy who have an elevated Lp-PLA2 have a 64% increased risk of ischemic stroke. 
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